Women in Science and Engineering at Yale (2020 Edition)

Stavroula Hatzios, Ph.D.

Assistant Professor, Department of Molecular, Cellular and Developmental Biology and in the Microbial Sciences Institute

The primary goal of Stavroula Hatzios’s research is to understand how pathogen-induced oxidative stress alters host-cell signaling at the post-translational level. In addition to using a combination of chemical proteomics, genetics, and complex infection models, she also uses mass-spectrometry approaches to identify novel metabolites in gastrointestinal bacteria. This research applies to improving the diagnosis and treatment of certain diseases, including gastrointestinal cancers.

Chemical proteomic approach for the detection of oxidized cysteines (Sox) in cells infected with the gastric cancer-causing pathogen Helicobacter pylori. Proteins with significantly decreased cysteine reactivity during infection are shown. Photo credit: Stavroula Hatzios